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DRUG THERAPIES FOR HEALTHY BONES: FLUORIDE
December 20, 2010
I used to prescribe sodium fluoride because it stimulates bone formation. But the bone formed turned out not to be of high quality—and sometimes even abnormal—resulting in dense, but fragile, bones and increases in the rate of fractures. Side effects include gastrointestinal problems and joint and/or bone pain, and it is potentially toxic in high doses. With newer, far better options, the benefits no longer outweigh the drawbacks, so my advice is to avoid it.
However, studies are under way on lower doses in special slow-release formulations that may build bone and decrease fractures, as well as reduce or eliminate side effects. Low doses (45 to 75 mg daily) are already used in Europe, with apparently satisfactory results, but haven’t been approved by the FDA here as of yet. More study is needed, but perhaps lower doses that keep fluoride safe and effective will bring this drug back into favor. It should be a relatively inexpensive option if it does prove useful in the future. If it does make a comeback, you may want to take it along with calcium and vitamin D supplements, and possibly another medicine that blocks bone breakdown.
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